Amide Bond Formation via Reversible, Carboxylic Acid-Promoted Lactone Aminolysis
نویسندگان
چکیده
منابع مشابه
Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines.
Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.
متن کاملGlycoside bond formation via acid-base catalysis.
Acid-base catalyzed glycosyl donor and then glycosyl acceptor activation with phenylboron difluoride or diphenylboron fluoride permits hydrogen bond mediated intramolecular S(N)2-type glycosidation in generally high anomeric selectivity.
متن کاملMetal-catalysed approaches to amide bond formation.
Amongst the many ways of constructing the amide bond, there has been a growing interest in the use of metal-catalysed methods for preparing this important functional group. In this tutorial review, highlights of the recent literature have been presented covering the key areas where metal catalysts have been used in amide bond formation. Acids and esters have been used in coupling reactions with...
متن کاملDirect amide formation from unactivated carboxylic acids and amines.
The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 °C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.
متن کاملCatalytic amide formation from non-activated carboxylic acids and amines.
The amide functionality is found in a wide variety of biological and synthetic structures such as proteins, polymers, pesticides and pharmaceuticals. Due to the fact that synthetic amides are still mainly produced by the aid of coupling reagents with poor atom-economy, the direct catalytic formation of amides from carboxylic acids and amines has become a field of emerging importance. A general,...
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ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2010
ISSN: 1083-6160,1520-586X
DOI: 10.1021/op1001269